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[Ala11, D-Leu15]-Orexin B
Cat. No. OX-040
Structure:
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Other Names:
[Ala(11), D-Leu(15)]orexin-B, [Ala11, d-Leu15]–OrxB, Selective OX2R agonist
Activity:
Potent and selective orexin2 receptor agonist
[Ala11, D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist with 400-fold selectivity for OX2 over OX1 receptors, possessing EC50 values of 0.13 and 52 nM for human OX2 and OX1 receptors respectively. [Ala11,D-Leu15]-Orexin B increases social novelty seeking and can decrease anxious and depressive behaviour in animal models.
Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett. 13 111 PMID: 12467628
Borgland et al (2008), Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. European J. Neuroscience 28 1545 PMID: 18793323
Staton et al (2018) Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression, Neuropharmacology 143 79 PMID: 30240784
Related areas
All peptides >
All orexin receptor modulators >
All neuroscience categories >
All appetite regulation categories >
Technical Data
| Structure | H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| CAS Number | 532932-99-3 |
| Molecular Weight | 2857.28 |
| Formula | C189H284N54O56S |
| Sequence | RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.30 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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