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Cortistatin 14
Cat. No. SS-020
Structure:
H-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (disulfide bridge between cysteine 2 and cysteine 13)
Other Names:
CST-14
Activity:
Endogenous somatostatin like neuropeptide
Cortistatin 14 is an endogenous neuropeptide that has structural and functional similarities to somatostatin 14. Cortistatin 14 shows potency at all five somatostatin receptors (sst1 - sst5) and prevents somatostatin 14 from binding to them (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Cortistatin 14 has neuronal depressant and sleep modulating properties and co-exists with GABA within the cortex and hippocampus. Cortistatin 14 also binds with much lower potency to the ghrelin and MRGPRX2 receptors.
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157 PMID: 9125122
Jiang et al (2018) The role of Cortistatin-14 in the gastrointestinal motility in mice. Pharmacol. Rep 70 355 https://doi.org/10.1016/j.pharep.2017.09.004
Jiang et al (2018) Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 9 767 PMID: 30072893
Related areas
All peptides >
All somatostatin receptor modulators >
All endocrinology research areas >
All neuroscience research areas >
Technical Data
| Structure | H-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (disulfide bridge between cysteine 2 and cysteine 13) |
| CAS Number | 193829-96-8 |
| Molecular Weight | 1721.03 |
| Formula | C81H113N19O19S2 |
| Sequence | PCKNFFWKTFSSCK |
| Modifications | Disulfide bridge between cysteine 2 and cysteine 13 |
Solubility and Storage
| Solubility | Soluble to 0.70 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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