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Somatostatin 14
Cat. No. SS-010
Structure:
H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (disulfide bridge between cysteine 3 and cysteine 14)
Other Names:
Somatostatin; Growth hormone inhibiting hormone, SRIF 14
Activity:
Endogenous somatostatin receptor agonist
Somatostatin, also known as growth hormone inhibiting hormone, is an endogenous peptide hormone. Somatostatin has two active forms produced by the alternative cleavage of a single preproprotein, one consisting of 14 amino acids, the other consisting of 28 amino acids. Somatostin 14 is the shorter isoform and works primarily in the brain, while the 28 amino acid form acts in the GI tract. Somatostatin 14 regulates the endocrine system and affects neurotransmission and cell proliferation though interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
Dileepan et al (1985) Somatostatin: a metabolic regulator. Life Sci. 37 2335 PMID: 2867445
Günther et al (2018) Pharmacological Reviews 70(4) 763 DOI: https://doi.org/10.1124/pr.117.015388
O'Toole and Sharma S. (2021) Physiology, Somatostatin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021 Jan https://www.ncbi.nlm.nih.gov/books/NBK538327/
Related areas
All peptides >
All somatostatin receptor modulators >
All endocrinology research areas >
All neuroscience research areas >
Technical Data
| Structure | H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (disulfide bridge between cysteine 3 and cysteine 14) |
| CAS Number | 51110-01-1 |
| Molecular Weight | 1637.88 |
| Formula | C76H104N18O19S2 |
| Sequence | AGCKNFFWKTFTSC |
| Modifications | Disulfide bridge between cysteine 3 and cysteine 14 |
Solubility and Storage
| Solubility | Soluble to 0.30 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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