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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Ac2-26
Cat. No. PP-100
Structure:
Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH
Other Names:
AnxA1 mimetic peptide, Lipocortin-1 (2-26), Annexin-1 (2-26) (human)
Activity:
Annexin/lipocortin 1 mimetic
Ac2-26 is the N terminal fragment of annexin A1 and an annexin/lipocortin 1 mimetic. Ac2-26 can inhibit leukocyte extravasation, reduce neutrophil adhesion and emigration, promote detachment of neutrophils from activated mesenteric endothelium and accelerate epithelial wound repair. Local intestinal delivery of Ac2-26 encapsulated within targeted polymeric nanoparticles accelerates healing of murine colonic wounds after biopsy-induced injury.
Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60 PMID: 12644621
Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215 PMID: 25664854
Possebon et al (2018) Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD, International Immunopharmacology, 63 270 PMID: 30121452
Related areas
All peptides >
All protein-protein interaction modulators >
All immunology research categories >
Technical Data
| Structure | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH |
| CAS Number | 151988-33-9 |
| Molecular Weight | 3089.46 |
| Formula | C141H210N32O44S |
| Sequence | Ac-AMVSEFLKQAWFIENEEQEYVQTVK |
| Modifications | N terminal acetyl |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in phosphate buffered saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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