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Products
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- Technical support
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CGRP (8-37) (rat)
Cat. No. CG-020
Structure:
H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
Other Names:
CGRP 8-37 (rat), Calcitonin Gene-Related Peptide 8-37 (rat), α-CGRP (8-37)
Activity:
CGRP antagonist
CGRP (8-37) (rat) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity and acts as a competitive and highly selective CGRP1 receptor antagonist. CGRP (8-37) (rat) possesses hypothermic and antinociceptive effects and can abolish mechanical and thermal allodynia in chronic central neuropathic pain models.
Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. Trends Pharmacol Sci. 16(12) 424 PMID: 8578616
Bennett et al (2000) Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chronic central pain. Pain. 86(1-2) 163 PMID: 10779673
Janzadeh et al (2020) The role of CGRP receptor antagonist (CGRP8-37) and Endomorphin-1 combination therapy on neuropathic pain alleviation and expression of Sigma-1 receptors and antioxidants in rats. J. Chemical Neuroanatomy 106 101771 PMID: 32092447
Related areas
All peptides >
All calcitonin and related receptor modulators >
All endocrinology research areas >
All pain research categories >
Technical Data
| Structure | H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 |
| CAS Number | 129121-73-9 |
| Molecular Weight | 3127.55 |
| Formula | C138H224N42O41 |
| Sequence | VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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