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Products
Pharmacology
Type
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- Technical support
- Resources
Penetratin
Cat. No. CP-040
Structure:
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Other Names:
Antennapedia peptide, Antennapedia (43-58)
Activity:
Cell penetrating peptide
Penetratin is a 16-mer peptide derived from the third helix of the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization. Penetratin is able to translocate through the plasma membrane to the cytosol and nucleus, and can facilitate internalization of macromolecular cargoes into living cells, usually by the formation of a conjugate or fusion protein. Penetratin is commonly used as an alternative or complement to Tat peptide for enhancing the cellular uptake of nanoparticles.
Pietersz and Apostolopoulos (2001) A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway. Vaccine 19(11-12) 1397 PMID: 11163662
Dupont et al (2011) Penetratin story: an overview. Methods Mol Biol. 683 21 PMID: 21053119
Patel et al (2019) Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Sci Rep 9 6298 PMID: 31000738
Related areas
Technical Data
| Structure | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH |
| CAS Number | 188842-14-0 |
| Molecular Weight | 2246.80 |
| Formula | C104H168N34O20S |
| Sequence | RQIKIWFQNRRMKWKK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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