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Products
Pharmacology
Type
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- Technical support
- Resources
Bid BH3
Cat. No. PP-080
Structure:
H-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg-OH
Other Names:
Bid BH3 peptide, BIDBH3
Activity:
Fragment of the BH3 domain of BID
Bid BH3 peptide is a fragment derived from the BH3 domain of the pro-apoptotic protein Bid (BH3-interacting domain death agonist). Bid is a member of the BH3-only subset of the BCL-2 family of proteins that are critical control points in apoptosis and Bid is the first of the BH3 subset reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax and the BH3 peptide domain, excised from the entire BH3-only molecule, can function as a specific death ligand itself
Letai et al (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics, Cancer Cell 2(3) 183 PMID: 12242151
Billen et al (2008) Bid: a Bax-like BH3 protein. Oncogene 27 S93 PMID: 19641510
Jeng et al (2018) BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis. Curr Opin Physiol. 3 71 PMID: 30334018
Related areas
All peptides >
All protein-protein interaction modulators >
All regulated cell death research categories >
All cancer research categories >
Technical Data
| Structure | H-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg-OH |
| Molecular Weight | 2309.59 |
| Formula | C95H161N3 O32S |
| Sequence | EDIIRNIARHLAQVGDSMDR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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