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Products
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Bim BH3
Cat. No. PP-070
Structure:
H-Asp-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg-OH
Other Names:
Peptide IV, Bim BH3 peptide
Activity:
BH3 only protein Bim fragment
Bim BH3 is a 26-residue fragment from the BH3 only protein Bim. BH3 only proteins are pro-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development, tissue homeostasis and immunity. The mammalian BH3-only proteins include Bad, Bid, Bik/NBK, Bim/Bod, Bmf, Hrk/DP5, Noxa and Puma/BBC3. Bim BH3 binds to Bcl-2, Bcl-xL and Mcl-1 with very high affinity.
Zhong et al (2005) Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121(7) 1085 PMID: 15989957
Giam et al (2008) BH3-only proteins and their roles in programmed cell death. Oncogene 27 S128 PMID: 19641498
Lee et al (2009), High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL. Angewandte Chemie International Edition 48 4318 PMID: 19229915
Related areas
All peptides >
All protein-protein interaction modulators >
All regulated cell death research categories >
Technical Data
| Structure | H-Asp-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg-OH |
| CAS Number | 721885-31-0 |
| Molecular Weight | 3269.69 |
| Formula | C145H222N44O41S |
| Sequence | DMRPEIWIAQELRRIGDEFNAYYARR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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