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Products
Pharmacology
Type
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- Custom services
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- Technical support
- Resources
Transportan
Cat. No. CP-030
Structure:
H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-OH
Other Names:
[Lys13]galparan
Activity:
Cell penetrating peptide
Transportan is a 27 amino acid chimeric peptide consisting of 12 amino acids from the amino terminal of galanin and the 14 amino acid peptide mastoparan connected via a lysine residue. Transportan possesses characteristics of both galanin and mastoparan as it inhibits the binding of galanin to the GALR-1 receptor as well as modulating the activity of G proteins through inhibition of GTPase. Transportan is a cell-penetrating peptide which can penetrate into many cell types in a rapid and efficient way. In the cell interior, Transportan localizes mostly in membranous structures and is conveyed into the nuclei, where it concentrates in the nucleoli.
Pooga et al (1998) Cell penetration by transportan. FASEB J. 12(1) 67 PMID: 9438412
Pooga et al (2001), Cellular translocation of proteins by transportan. FASEB J. 5 1451 PMID: 11387254
Aguiar etal (2019) Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites. Med. Chem. Commun. 10 221 PMID: 30881610
Related areas
All cell penetrating peptides >
All galanin receptor modulators >
Technical Data
| Structure | H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-OH |
| Molecular Weight | 2841.47 |
| Formula | C134H226N34O33 |
| Sequence | GWTLNSAGYLLGKINLKALAALAKKIL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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