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Products
Pharmacology
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- Technical support
- Resources
PUMA BH3
Cat. No. PP-050
Structure:
H-Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg-OH
Other Names:
PUMA BH3 peptide
Activity:
BH3 domain fragment of PUMA
PUMA BH3 is a sequence derived from the BH3 domain of the BH3-only protein PUMA (p53 up-regulated modulator of apoptosis]. PUMA, also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein and member of the Bcl-2 protein family. Bcl-2 family proteins regulate the mitochondrial apoptosis pathway by controlling mitochondrial outer membrane permeabilization. The BCL2 protein family is divided into three subfamilies: antiapoptotic BCL2 family proteins, including BCL2, BCLxL, and MCL1; proapoptotic multi-domain BCL2 family proteins, including BAK, BAX, and BOK, and proapoptotic BH3-only proteins, including BIM, PUMA, BID, BAD, NOXA, BMF, HRK, and BIK. PUMA acts as a key mediator of cytosolic proapoptotic p53 function by freeing cytosolic p53 from inactive complexes with BCL-xL
Cartron et al (2004) The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA. Molecular Cell, 16(5) 807 PMID: 15574335
Fisher et al (2008) Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PNAS 105(51) 20327 PMID: 19074266
Ye et al (2020) Characterization of an alternative BAK-binding site for BH3 peptides. Nat Commun 11 3301 PMID: 32620849
Related areas
All peptides >
All protein-protein interaction modulators >
All regulated cell death research categories >
Technical Data
| Structure | H-Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg-OH |
| Molecular Weight | 3049.33 |
| Formula | C128H202N42O43S |
| Sequence | EEQWAREIGAQLRRMADDLNAQYER |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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