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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
VIP
Cat. No. VP-010
Structure:
H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Other Names:
VIP (human, rat, mouse, rabbit, canine, porcine), Vasoactive intestinal peptide, Aviptadil
Activity:
Endogenous VPAC1 and VPAC2 agonist.
VIP (Vasoactive intestinal peptide) is a 28 amino acid peptide originally isolated from swine intestines and found to be vasoactive by dilating arterioles. VIP is widely distributed in both the central and peripheral nervous system and is released by both neurons and immune cells. VIP has pleiotropic effects as a neurotransmitter, immune regulator, vasodilator and secretagogue. VIP is a master circadian regulator, as its deletion in mice causes a cycling shift in wake/sleep duration with reduced food intake and body weight.
Laburthe and Couvineau (2002) Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP. Regul Pept. 08(2-3) 165 PMID: 12220741
Delgado and Ganea (2013) Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions. Amino Acids. 45(1) 25 PMID: 22139413
Bains (2019) Vasoactive Intestinal Peptide Deficiency Is Associated With Altered Gut Microbiota Communities in Male and Female C57BL/6 Mice. Front. Microbiology 10 2689 PMID: 31849864
Related data
All peptides >
All vasoactive intestinal peptide (VIP) receptor modulators >
All endocrinology categories >
All cardiovascular categories >
Technical Data
| Structure | H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| CAS Number | 40077-57-4 |
| Molecular Weight | 3325.80 |
| Formula | C147H238N44O42S |
| Sequence | HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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