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Products
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Orexin B (mouse)
Cat. No. OX-030
Structure:
H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Activity:
Endogenous OX1 and OX2 receptor agonist
Orexin B (mouse) is an endogenous agonist at orexin receptors, which preferentially activates OX2 over OX1. Orexin B (mouse) stimulates food consumption in a similar manner to orexin A, but with a shorter duration of action. Orexin B (mouse) is also involved in the sleep-wake cycle and hypothalamic functions.
Smart (1999) Orexins: a new family of neuropeptides. Br J Anaesth. 83(5) 695 PMID: 10690128
Preti (2002) Orexins (hypocretins): their role in appetite and arousal. Curr. Opin. Investig. Drugs. 3(8) 1199 PMID: 12211415
Chieffi et al (2017) Orexin System: The Key for a Healthy Life. Front Physiol. 8 357 PMID: 28620314
Related areas
All peptides >
All orexin receptor modulators >
All neuroscience research categories >
All appetite regulation categories >
Technical Data
| Structure | H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| CAS Number | 202801-92-1 |
| Molecular Weight | 2936.44 |
| Formula | C126H215N45O34S |
| Sequence | RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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