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Products
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Orexin B (human)
Cat. No. OX-020
Structure:
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Activity:
Endogenous agonist at OX1 and OX2 receptors
Orexin B (human) is an endogenous agonist peptide at orexin receptors with some selectivity for OX2 (with Ki values of 420 and 36 nM for OX1 and OX2 receptors respectively). Orexin B (human) stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin B (human) is neuroprotective for dopaminergic neurons in animal models.
Smart (1999) Orexins: a new family of neuropeptides. Br J Anaesth. 83(5) 695 PMID: 10690128
Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol Pharmacol. 87(3) 525 PMID: 25552485
Shingo and Sakurai (2020) Evolution of Orexin Neuropeptide System: Structure and Function. Frontiers in Neuroscience 14 691 PMID: 32754010
Related areas
All peptides >
All orexin receptor modulators >
All neuroscience categories >
All appetite regulation categories >
Technical Data
| Structure | H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| CAS Number | 205640-91-1 |
| Molecular Weight | 2899.37 |
| Formula | C123H212N44O35S |
| Sequence | RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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