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Products
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Spexin
Cat. No. GA-010
Structure:
Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH2
Other Names:
Neuropeptide Q, NPQ, Spexin (36 - 49) amidated
Activity:
Endogenous galanin receptor 2/3 agonist
Spexin, or neuropeptide Q, is an endogenous galanin receptor 2/3 agonist with EC50 values of 45 and 112 nM respectively, and no significant activity at galanin receptor 1. Spexin is a satiety inducing peptide which inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet induced obese mice and rats. Spexin gene expression is markedly down regulated in obese human fat. Spexin also posseses anxiolytic properties.
Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity 22(7) 1643 PMID: 24550067
Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155(5) 1864 PMID: 24517231
Shuang-Yu et al (2019) Emerging Roles of NPQ/Spexin in Physiology and Pathology. Frontiers in Pharmacology 10 457 PMID: 31133851
Related areas
All peptides >
All galanin receptor modulators >
All neuroscience research categories >
All appetite regulation research categories >
All endocrinology research categories >
Technical Data
| Structure | Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH2 |
| CAS Number | 1370290-58-6 |
| Molecular Weight | 1619.90 |
| Formula | C74H114N20O19S |
| Sequence | NWTPQAMLYLKGAQ-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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