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OXA (17-33)

Cat. No. OX-010

Structure:

Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2

Activity:

Orexin-1 receptor (OX1) agonist

Price Qty
1 mg    £ 85.00

OXA (17-33) is a truncated orexin fragment, identified as the shortest active peptide with 23-fold selectivity for orexin 1 (OX1) (EC50=8.29 nM) over orexin 2 (OX2) receptors (EC50 = 187 nM).

Darker et al (2001) Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg. Med. Chem. Lett. 11(5) 737 PMID: 11266181

German et al (2013)Truncated Orexin Peptides: Structure-Activity Relationship Studies. ACS Med Chem Lett. 4(12) 1224 PMID: 24707347


Related areas

All peptides >
All orexin receptor modulators >
All neuroscience categories >
All appetite regulation categories >


Technical Data

Structure Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
CAS Number 343268-91-7
Molecular Weight 1749.00
Formula C79H125N23O22
Sequence YELLHGAGNHAAGILTL-NH2
Modifications C terminal amide

Solubility and Storage

Solubility Soluble to 1 mg/ml in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

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