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KSL 128114
Cat. No. PP-030
Structure:
Ac-(D)Arg-Arg-(D)Arg-Gly-(D)Arg-Lys-(D)Lys-Arg-(D)Arg-Ser-His-Trp-Tle-Chg-Asp-Ile-OH
Activity:
Binds the PDZ1 domain of syntenin
KSL 128114 is a potent, and
metabolically stable peptide inhibitor of syntenin, which binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and
mouse hepatic microsomes and shows an inhibitory
effect on primary glioblastoma cell viability. KSL 128114 significantly extends survival time in a patient derived glioblastoma xenograft mouse model.
Haugaard-Kedström et al (2021) A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem. 64 1423 PMID: 33502198
Related areas
All peptides >
All protein-protein modulators >
All cancer research categories>
Technical Data
| Structure | Ac-(D)Arg-Arg-(D)Arg-Gly-(D)Arg-Lys-(D)Lys-Arg-(D)Arg-Ser-His-Trp-Tle-Chg-Asp-Ile-OH |
| Molecular Weight | 2201.6 |
| Formula | C94H163N39O20 |
| Sequence | Ac-rRrGrKkRrSHW(Tle)(Chg)DI |
| Modifications | N terminal is acetylated, arginines 1, 3, 5 and 9 and lysine 7 are D amino acids, Tle is tert butyl glycine and Chg is cyclohexylglycine |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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