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Cys-Pexiganan

Cat. No. AM-230

Structure:

H-Cys-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2

Activity:

The broad-spectrum antibacterial pexiganan with an additional N-terminal cysteine
Price Qty
1 mg    £ 175.00
Cys-Pexiganan is the broad-spectrum antibacterial pexiganan with an additional N-terminal cysteine attached. Pexiganan is a 22-amino acid analog of the naturally occurring antimicrobial magainin2, extracted from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria and is the best-studied AMP to date for therapeutic purposes. The addition of the N-terminal cysteine in Cys-pexiganan allows immobilization of pexiganan as a novel approach towards endowing material surfaces with bactericidal properties as well as attachment of fluorescent or biotin tags.

Ge et al (1999) In Vitro Antibacterial Properties of Pexiganan, an Analog of Magainin. Antimicrob. Agents Chemother. 43(4) 782 PMID: 10103181

Gottler and Ramamoorthy (2009) Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin. Biochim. Biophys. Acta - Biomembranes 1788(8) 1680 PMID: 19010301

Rodríguez-Rojas et al (2020) Antimicrobial Peptide Induced-Stress Renders Staphylococcus aureus Susceptible to Toxic Nucleoside Analogs. Front. Immunol. 11 1686 PMID: 33133056

Teixeira et al (2022) Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose acetate-containing poly(vinyl alcohol) electrospun mats for potential wound care purposes. Int J Biol Macromol. 209(Pt A) 1526 PMID: 35469947

Teixeira et al (2022) Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced poly(vinyl alcohol) electrospun mats doped with Tiger 17 and pexiganan peptides for prospective wound healing applications. Biomaterials Advances (137) 212830 https://doi.org/10.1016/j.bioadv.2022.212830

Marta et al (2024) Comparison of the adsorption of linear and cyclic antimicrobial peptides onto cellulosic compounds-reinforced poly(vinyl alcohol) films using QCM-D, Colloids and Surfaces A: Physicochemical and Engineering Aspects 687 133490 https://doi.org/10.1016/j.colsurfa.2024.133490


Related areas

All antimicrobial peptides >
All immunology research categories >


Technical Data

Structure H-Cys-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2
Molecular Weight 2580.35
Formula C125H215N33O23S
Sequence CGIGKFLKKAKKFGKAFVKILKK-NH2
Modifications C terminal amide

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC
Safety Data Sheet Cys-Pexiganan MSDS_602bbb739cd6f.pdf

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

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Italy
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China

BIOHUB INTERNATIONAL 

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Japan

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