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MG 132
Cat. No. PI-030
Structure:
Z-Leu-Leu-Leu-CHO
Other Names:
Z-LLL-al, Z-Leu-Leu-Leu-CHO
Activity:
Inhibits the chymotrypsin like activity of the 20S proteasome
MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-α-induced NF-κB activation and IκBα degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.
Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941 PMID: 11911275
Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572 PMID: 8830056
Ma et al (2020) Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. 30 678 PMID: 32541865
Related areas
All peptides >
All proteasome modulators >
All immunology research categories >
Technical Data
| Structure | Z-Leu-Leu-Leu-CHO |
| CAS Number | 133407-82-6 |
| Molecular Weight | 475.63 |
| Formula | C26H41N3O5 |
| Sequence | Z-LLL-CHO |
| Modifications | N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal |
Solubility and Storage
| Solubility | Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL) |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >98% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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