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Leupeptin hemisulfate
Cat. No. PI-010
Structure:
Ac-Leu-Leu-Arginal
Activity:
Reversible inhibitor of trypsin like and cysteine proteases,
Leupeptin is a reversible inhibitor of trypsin-like proteases and cysteine proteases, including trypsin, plasmin, papain, cathepsin B, H and L1-3. Leupeptin also blocks various apoptotic
pathways in T cells and can inhibit activation-induced programmed cell death. Leupeptin is widely used in cell lysis buffers to protect proteins from degradation, at a typical working concentration of 1 μM (0.5 μg/mL).
Aoyagi et al (1969) Leupeptins, new protease inhibitors from actinomycetes. J. Antibiot. 22 283 PMID: 5810993
Barrett et al (1981) Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol. 80 535 PMID: 7043200
Sarin et al (1995) A protease-dependent TCR-induced death pathway in mature lymphocytes. J. Immunol. 154(11) 5806 https://www.jimmunol.org/content/154/11/5806
PubChem - Leupeptin hemisulphate
Related areas
All peptides >
All other protease modulators >
All regulatated cell death research categories >
Technical Data
| Structure | Ac-Leu-Leu-Arginal |
| CAS Number | 103476-89-7 |
| Molecular Weight | 475.04 |
| Formula | C20H38N6O4.½H2SO4 |
| Sequence | LLR |
| Modifications | Leu-1 = N-terminal Acetyl, Arginine-3 = Arginal |
Solubility and Storage
| Solubility | Soluble to 10 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, dark and frozen |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Leupeptin Hemisulfate MSDS_605c7c72e5092.pdf |
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