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Products
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Z-VAD-FMK
Cat. No. PI-250
Structure:
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Other Names:
Z-Val-Ala-Asp(OMe)-FMK
Activity:
Pan-caspase inhibitor
Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing and apoptosis induction in tumour cells in vitro with an IC50 of 0.0015 - 5.8 mM). Z-VAD-FMK is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Z-VAD-FMK is active in vivo and can inhibit apoptosis in numerous settings.
Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21 PMID: 8670109
Ilangovan et al (2003) Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J. Biol. Chem. 278(33) 30993 PMID: 12783893
Simmons et al (2009) Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect. Dis. Obstet. Gynecol. 2009 749432 PMID: 20069051
Related areas
All peptides >
All caspase modulators >
All cancer research categories >
Technical Data
| Structure | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone |
| CAS Number | 187389-52-2 |
| Molecular Weight | 467.49 |
| Formula | C22H30FN3O7 |
| Sequence | Z-VAD-FMK |
| Modifications | Benzyloxycarbonyl (Z) at N terminal, Fluoromethylketone (FMK) at C terminal |
Solubility and Storage
| Solubility | Soluble to 10 mg/mL in DMSO |
| Appearance | White lyophilised solid |
| Storage | Store dry, dark and frozen |
Batch Specific Data
| Purity | >98% by TLC |
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