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Mca-SEVNLDAEFR-K(Dnp)-RR-NH2
Cat. No. PS-020
Structure:
Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2
Other Names:
Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide
Activity:
FRET substrate for beta-secretase 1 (BACE-1)
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, also knowm as Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide, is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
Koike et al (1999) Thimet Oligopeptidase Cleaves the Full-Length Alzheimer Amyloid Precursor Protein at a β-Secretase Cleavage Site in COS Cells. J. Biochem. 126(1) 235 PMID: 10393344
Klaver et al (2010), Glycosaminoglycan‐induced activation of the β‐secretase (BACE1) of Alzheimer’s disease. J. Neurochem. 112 1552 PMID: 20067575
Related areas
All secretase modulators >
All fluorescent labelled peptides >
All substrate peptides >
All neuroscience research areas >
Technical Data
| Structure | Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 |
| CAS Number | 438625-61-7 |
| Molecular Weight | 2001.1 |
| Formula | C86H125N27O29 |
| Sequence | Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 |
| Modifications | 7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 11, C terminal amide |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 MSDS_602bfadfe8579.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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