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Products
Pharmacology
Type
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- Custom services
- Ordering
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- Technical support
- Resources
LL 37 (human), 5-FAM
Cat. No. AM-004
Structure:
5-FAM-Ahx-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
Activity:
N-terminally carboxyfluoresceinated derivative of the host defence peptide LL 37
LL 37 (human), 5-FAM is the N-terminally carboxyfluoresceinated derivative of the host defence peptide LL 37. The carboxyfluorescein group is attached via a 6-carbon spacer, 6-aminohexanoic acid (Ahx). The presence of the carboxyfluorescein tag allows fluorescent detection of LL 37. We also offer unlabelled LL 37 (AM-001) and the biotinylated version of LL 37 (AM-003).
Kahlenberg and Kaplan (2013) Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J. Immunol. 191(10) 4895 PMID: 24185823
Bandurska et al (2015) Unique features of human cathelicidin LL‐37. BioFactors 41 289 PMID: 26434733
Chen et al (2018) Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer. Cell Physiol.Biochem. 47 1060 PMID: 29843147
Related areas
All fluorescent labelled peptides >
All antimicrobial peptides >
Technical Data
| Structure | 5-FAM-Ahx-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH |
| Molecular Weight | 4963.6 |
| Formula | C226H351N61O58 |
| Sequence | 5FAM-Ahx-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
| Modifications | 5-FAM is attached to the N teminal via a 6-aminohexanoic acid linker |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | LL 37 (human), 5-FAM MSDS_602bf5e1f08c0.pdf |
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