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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
LAP
Cat. No. AM-190
Structure:
H-Ala-Ala-Leu-Glu-Ala-Lys-Ile-Cys-His-Gln-Ile-Glu-Tyr-Tyr-Phe-Gly-Asp-Phe-NH2
Other Names:
La peptide
Activity:
Inhibits viral IRES mediated translation
LAP (for La peptide) corresponds to amino acids 11 to 28 from the N-terminal “La motif” of La, a 52-kDa autoantigen found in patients with systemic lupus erythematosus, and one of the first cellular proteins identified to interact with viral internal ribosome entry site (IRES) elements and stimulate poliovirus (PV) and hepatitis C virus (HCV) IRES-mediated translation. LAP efficiently inhibits viral IRES-mediated translation in vitro. LAP does not bind RNA directly but blocks La binding to IRNA and PV 5'-UTR.
Izumi et al (2004) A Peptide from Autoantigen La Blocks Poliovirus and Hepatitis C Virus Cap-Independent Translation and Reveals a Single Tyrosine Critical for La RNA Binding and Translation Stimulation. J.Virol. 78(7) 3763 DOI: 10.1128/
Technical Data
| Structure | H-Ala-Ala-Leu-Glu-Ala-Lys-Ile-Cys-His-Gln-Ile-Glu-Tyr-Tyr-Phe-Gly-Asp-Phe-NH2 |
| Molecular Weight | 2117.41 |
| Formula | C99H141N23O27S |
| Sequence | AALEAKICHQIEYYFGDF-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | LAP MSDS_602be54ef2a30.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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