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Interleukin-33
Published on September 4th 2026
Interleukin-33 (IL-33) is an alarmin and cytokine that has potent biological effects in various tissues. It acts on a broad array of immune cell populations and is involved in many processes associated with health and disease. A recent review by Serve and Löhning discusses the biology of IL-33 and its receptor, ST2, and the functional relevance of IL-33–ST2 signalling. It focuses particularly on the differential regulation of IL-33 sensitivity in distinct cell types in diverse tissue settings and describes the effects of IL-33 in various diseases, including viral infections, cancer, graft-versus-host disease, colitis, autoimmunity, chronic obstructive pulmonary disease, asthma and allergy. The roles of IL-33 in physiological reactions such as fat tissue biology and tissue regeneration are also discussed.
Serve and Löhning provide a comprehensive understanding of IL-33 signalling and its potential as a target for developing new treatments.
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