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Therapeutic potential of targeting the orexin system in sleep disorders
Published on August 3rd 2026
Sleep is emerging as a key health topic in modern society. The prevalence of and focus on sleep–wake disorders is increasing, which has led to a large interest from the pharmaceutical industry to develop new treatments targeting sleep biology (drugs that have the potential to mimic normal sleep–wake physiology). The orexin (also known as hypocretin) system is one of the key targets and regulators of sleep and wakefulness and in a recent review, Kornum et al discuss the mechanisms by which loss of orexin signalling is involved in narcolepsy type 1 and whether loss and or disruption of orexin signalling might have a role in other sleep disorders such as narcolepsy type 2, idiopathic hypersomnia and obstructive sleep apnoea. Current and emerging therapies for sleep disorders involving orexin, such as orexin receptor antagonists for insomnia and orexin receptor agonists for narcolepsy are also reviewed.
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