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Cyclic peptides are having a moment
Published on June 3rd 2026
As drugs, traditional linear peptides suffer from some drawbacks -.they must be injected, and they can suffer from poor metabolic stability, membrane permeability, and oral bioavailability. Cyclic peptides, in contrast, have better drug-like properties owing to their enhanced conformational rigidity, elimination of unstable terminal residues, and better metabolic stability. These traits also allow them when medicines to be taken in pill form. A recent analysis by CAS, a division of the American Chemical Society that specializes in scientific-knowledge management, reveals that the oral delivery of cyclic peptides is currently gaining attention. What may be surprising is that metabolic disorders like obesity are actually a relatively minor area of research for cyclic peptides. CAS finds thast the top three areas are cancer, infection, and inflammatory diseases.
Read more > Cyclic peptides are having a moment
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