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The genetics of obesity: aetiology, prevention and therapy
Published on April 13th 2026
Obesity is a complex, multifactorial condition with a strong genetic basis, encompassing monogenic, oligogenic and polygenic contributions. More than 1 billion people worldwide have obesity, including 150 million children. Since the discovery of leptin, over 85 monogenic forms have been identified, characterized by early-onset obesity with impaired appetite regulation, usually associated with neurodevelopmental (and other) phenotypes, making monogenic obesity mostly syndromic. However, genome-wide association studies have identified over 1,000 loci associated with weight variation. A recent review by Bonnefond et al highlights how advances in human genetics have translated into innovative therapeutic strategies, and shows how genetic discoveries have deepened understanding of obesity pathophysiology, and accelerated precision medicine.
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