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Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting
Published on November 4th 2024
Decades of research supports the link between Alzheimer disease (AD) and somatostatin (somatotropin-releasing inhibitory factor (SRIF)). SRIF and SRIF expressing neurons play an essential role in brain function, modulating hippocampal activity and memory formation, and loss of these neurons in the brain is at the centre of a series of pathological events driven by amyloid-β peptide (Aβ) which lead to cognitive decline and dementia.
The connection between SRIF and AD extends to neuropsychiatric symptoms, seizure activity, and inflammation, with SRIF or SRIF receptor agonist administration able to enhance cognition. SRIF receptor subtype-4 activation in particular has the potential to mitigate learning and memory decline, reduce comorbid symptoms, and enhance enzymatic degradation of Aβ in the brain. A recent review by Sandoval and Witt reviews the links between SRIF and AD along with the therapeutic implications.
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