Cell penetrating peptides

Cell penetrating peptides (CPPs) are a class of peptides that possess the ability to cross cell membranes and deliver various types of cargoes, including drugs, nucleic acids, and proteins, into cells.  CPPs are largely investigated in drug delivery applications in the context of many diseases, such as cancer, diabetes, and genetic disorders. While sharing this functionality and some common structural features, such as a high content of positively charged amino acids.  CPPs represent an extremely diverse group of elements, which can differentiate under many aspects.  A new review in ChemMedChem by Gori et al, characterises some of the most common characteristics of CPPs, their main distinctive features, mechanistic aspects that drive their function, and describes the most widely used techniques for their structural and functional studies, highlighting current gaps and future perspectives in this field.

Isca can manufacture and supply any CPP and conjugate it to a molecule of interest.  Many of our biologically active research peptides already have cell penetrating components which allow them to be active in vivo.  Please get in touch if you have any requirements.

See all our cell penetrating peptides here >