Formyl peptide receptor 2 - an emerging modulator of inflammation in the liver

Formyl peptide receptors (FPRs) are seven-membrane G-protein coupled receptors which recognize chemotactic signals to protect hosts from pathogenic infections and mediate inflammatory responses in the body. There are three isoforms of FPRs in humans—FPR1, FPR2, and FPR3—and they bind to N-formyl peptides, except FPR3, and to various endogenous agonists. Among FPR family members, FPR2 has a lower affinity for N-formyl peptides than FPR1 and binds with a wide range of endogenous or exogenous agonists.  Lee et al present the accumulating evidence that FPR2 is involved in the host’s defense against bacterial infection and inflammation in liver diseases, such as nonalcoholic fatty liver disease, liver fibrosis, and liver cancer, suggesting the pathophysiological relevance of FPR2 to the liver. 

In this review, up-to-date knowledge of FPR2, with general information on the FPR family, is provided, shedding light on the dual action of FPR2 in the liver and discussing the hepatoprotective roles of FPR2 itself and FPR2 agonists in mediating anti-inflammatory responses.

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Isca Formyl peptide receptor modulators >