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Dorsomorphin

Cat. No. KS-300

Structure:

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine

Other Names:

Compound C, BML 275

Activity:

AMPK inhibitor
Price Qty
5 mg    $ 115.00

Dorsomorphin is an ATP competitive inhibitor of AMP-activated protein kinase (AMPK) with a Ki of 109 nM and no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3.  Dorsomorphin inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6, and promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro as well as promoting neural differentiation of human pluripotent stem cells as part of a chemical cocktail.  Dorsomorphin can be used in a protocol to generate brain organoids from human induced pluripotent stem cells.  In vivo, dorsomorphin can inhibit formalin-induced inflammatory nociception in mice.

Yu et al (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 4(1) 33 PMID: 18026094

Hao et al (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One 3(8) e2904 PMID: 18682835

Vucicevic et al (2011) Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy (1) 40 PMID: 20980833

Aikawa et al (2020) Cell death induced by dorsomorphin in adult T-cell leukemia/lymphoma is AMPK-independent. FEBS J. 287(18) 4005 PMID: 32027454

Xinqiang et al (2022) Systemic administration of dorsomorphin relieves inflammatory nociception in the mouse formalin test. Int Immunopharmacol. 113(Pt A) 109337 PMID: 36274489


Related areas

All small molecules >
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Technical Data

Structure 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
CAS Number 866405-64-3
Molecular Weight 399.49
Formula C24H25N5O

Solubility and Storage

Solubility Soluble in DMSO to 3 mg/ml
Appearance Pale yellow solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity 98% by TLC, NMR conforms

Contact Information

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