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Products
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SB 431542
Cat. No. RK-030
Structure:
4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Other Names:
TGF-β RI Kinase Inhibitor VI
Activity:
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5, with an IC50 value of 94 nM, and also inhibits the related ALK4 and ALK7. SB 431542 inhibits TGF-β-induced epithelial to mesenchymal transition (EMT) migration, invasion and VEGF secretion in several human cancer cell lines, and suppresses TGF-β-induced proliferation of human osteosarcoma cells. SB 431542 can replace SOX2 in reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) and can also be used in a protocol to generate brain organoids from human iPSCs.
Laping (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 62(1) 58 PMID: 12065755
Halder et al (2005) A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7(5) 509 PMID: 15967103
Stanslowsky (2014) Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells. Stem Cell Res Ther. 5(2) 35 PMID: 24636737
Related areas
All small molecules >
All receptor serine/threonine kinase receptor modulators >
All stem cell research categories >
All cancer research categories >
Technical Data
| Structure | 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| CAS Number | 301836-41-9 |
| Molecular Weight | 384.4 |
| Formula | C22H16N4O3 |
Batch Specific Data
| Purity | 99% by hplc, NMR conforms |
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Recent citations
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