The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Y 27632 dihydrochloride
Cat. No. KS-250
Structure:
(R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide dihydrochloride
Other Names:
ROCK inhibitor, ROCK1 inhibitor
Activity:
Rho-associated protein kinase (ROCK) inhibitor
Y 27632 is a selective inhibitor of the Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases, with Ki's of 140 nM and 300nM against ROCK1 and ROCK2 respectively, and greater than 200-fold selectivity over other kinases. Y 27632 is cell-permeable, orally bioavailable and active in vivo, and can enhance stem cell survival and proliferation in culture. In combination with other agents, Y 27632 can be used to reprogram fibroblasts to mature neurons and can optimise naive human pluripotent stem cell (iSPC) growth and viability. Y 27632 has been used used to generate brain organoids from iPSCs.
Uehata et al (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389 990 PMID: 9353125
Ishizaki et al (2000) Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 57(5) 976 PMID: 10779382
Lancaster and Knoblich (2014) Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc. 9(10) 2329 PMID: 25188634
Hu et al (2015) Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell 7(2) 204 PMID: 26253202
Schafer et al (2023) An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell 186(10) 2111 PMID: 37172564
Related areas
All small molecules >
All kinase modulators >
All stem cell research categories >
Technical Data
| Structure | (R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide dihydrochloride |
| CAS Number | 129830-38-2 |
| Molecular Weight | 320.26 |
| Formula | C14H21N3O.2HCl |
Solubility and Storage
| Solubility | Up to 30 mg per ml in water, freely soluble in DMSO |
| Appearance | White solid |
| Storage | Stable for 2 years from date of purchase as supplied. Stock solutions may be stored at -20° for up to 3 months. |
Batch Specific Data
| Purity | 99% by HPLC, NMR conforms |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2024 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio