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N-Ethylmaleimide

Cat. No. PI-050

Structure:

1-Ethyl-1H-pyrrole-2,5-dione

Activity:

Sulfhydryl alkylating reagent
Price Qty
1 g    $ 59.00
N-Ethylmaleimide is a sulfhydryl alkylating reagent which has been used for blocking sulfhydryl containing reagents which interfere with glucose oxidase assays. N-Ethylmaleimide inactivates NADP-dependent isocitrate dehydrogenase and is also an endonuclease inhibitor. N-Ethylmaleimide is also a potent inhibitor of both Mg2+ and Ca2+/Mg2+-stimulated DNA fragmentation in rat liver nuclei.

Huang et al (1995) N-ethylmaleimide profiling of yeast NADP-dependent isocitrate dehydrogenase. Arch. Biochem. Biophys. 316(1) 485 PMID: 7840654

Lain et al (1994) Dependence of the folding and import of the precursor to mitochondrial aspartate aminotransferase on the nature of the cell-free translation system. J. Biol. Chem. 269(22) 15588 PMID: 8195205

Zhao and Brunger (2016) Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). J. Mol. Biol. 428 (9 Part B) 1912 PMID: 26546278


Related areas

All small molecules >
All dehydrogenase modulators >


Technical Data

Structure 1-Ethyl-1H-pyrrole-2,5-dione
CAS Number 128-53-0
Molecular Weight 125.13
Formula C6H7NO2
Sequence 1-Ethyl-1H-pyrrole-2,5-dione

Solubility and Storage

Solubility Soluble in ethananol
Appearance White solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity ≥98% by HPLC

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