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Synstatin

Cat. No. IG-050

Structure:

H-Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu-OH

Other Names:

SSTN, SSTN92-119

Activity:

Syndecan-1 mediated integrin activation inhibitor
Price Qty
1 mg    $ 229.00

Synstatin is a peptide derived from amino acids 92-119 of the mouse syndecan sequence and is the active site for the αvβ3 and αvβ5 integrin activation mechanism.  Syndecan is a critical regulator of these two integrins during angiogenesis and tumourigenesis, and this activation process can be blocked by the synstatin peptide.  Synstatin displays an IC50 of 100-300 nM when used in vitro to inhibit αvβ3 dependent adhesion and cell migration on vitronectin or in aortic ring angiogenesis assays.  Synstatin is a potent inhibitor of angiogenesis in vivo and blocks αvβ3 mediated tumour cell adhesion and migration and tumour formation in mouse models.

Beauvais et al (2009) Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med. 206(3) 691 PMID: 19255147

Rapraeger (2013) Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. 280(10) 2207 PMID: 23375101


Related areas

All peptides >
All integrin receptor modulators >
All protein-protein modulators >
All cancer research categories >


Technical Data

Structure H-Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu-OH
Molecular Weight 3032.31
Formula C133H207N35O46
Sequence LPAGEKPEEGEPVLHVEAEPGFTARDKE
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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