Substance P

NR-140-5MG 5mg 85.00 GBP

Product specification

Sequence: H-RPKPQQFFGLM-NH2
MW: 1347.6
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C63H98N18O13S
CAS: 33507-63-0
Solubility Soluble in dilute acid
Long Term Storage: We recommend storage desiccated, frozen and in the dark
Miscellaneous/General:

Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity.

Product Literature References

Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID: 9732370

Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID: 7541689

Zieglgänsberger (2019) Substance P and pain chronicity. Cell Tissue Res. 375(1) 227 https://doi.org/10.1007/s00441-018-2922-y

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