Sivelestat

PI-180-25MG 25mg 265.00 GBP
PI-180-5MG 5mg 75.00 GBP

Product specification

Sequence: N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
MW: 434.46
Purity: >95%
Appearance: White solid
Formula: C20H22N2O7S · xNa+ · yH2O
CAS: 127373-66-4
Solubility Soluble in DMSO
Long Term Storage: Store dry, dark and frozen
Miscellaneous/General:

Sivelestat, also known as ONO 5046, is a competitive inhibitor of human neutrophil elastase with an IC50 of 0.044 μM. Sivelistat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse but does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin or cathepsin G even at 100μM. Sivelistat is used in the treatment of acute respiratory failure and also improves neuropathic pain.

Product Literature References

Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase.
Biochem. Biophys. Res. Comm. 177(2) 814 https://doi.org/10.1016/0006-291X(91)91862-7

Weyer and Stucky (2015) Repurposing a leukocyte elastase inhibitor for neuropathic pain. Nat. Med. 21 429 https://doi.org/10.1038/nm.3861