For custom peptides please contact us on +44(0)1392 422205
To place an order please contact us on +44(0)1392 422205
The UK specialist in custom peptide synthesis
To discuss your project contact us on +44(0)1392 422205
Specialist custom peptide synthesis services
High quality peptides and biochemicals in stock now
t. +44(0) 1392 422205
f. +44(0) 1392 279510
|Formula:||C20H22N2O7S · xNa+ · yH2O|
|Solubility||Soluble in DMSO|
|Long Term Storage:||Store dry, dark and frozen|
Sivelestat, also known as ONO 5046, is a competitive inhibitor of human neutrophil elastase with an IC50 of 0.044 μM. Sivelistat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse but does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin or cathepsin G even at 100μM. Sivelistat is used in the treatment of acute respiratory failure and also improves neuropathic pain.
Product Literature References
Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase.
Biochem. Biophys. Res. Comm. 177(2) 814 https://doi.org/10.1016/0006-291X(91)91862-7
Weyer and Stucky (2015) Repurposing a leukocyte elastase inhibitor for neuropathic pain. Nat. Med. 21 429 https://doi.org/10.1038/nm.3861