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[Pyr1]-Apelin 13

Cat. No. AR-020

Structure:

Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

Other Names:

[Pyr1]-Apelin 13, [pGlu1]-apelin-13

Activity:

Endogenous agonist for the apelin APJ receptor
Price Qty
1 mg    $ 75.00
[Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator.

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471 PMID: 9792798

Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343

Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. TiPS 36(9) 560 PMID: 26143239

Guide to pharmacology -  [Pyr1]-Apelin 13


Related areas

All peptides >
All apelin receptor modulators >
All cardiovascular research categories >


Technical Data

Structure Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
CAS Number 217082-60-5
Molecular Weight 1533.8
Formula C69H109N22O16S
Sequence XRPRLSHKGPMPF
Modifications X is pGlu

Solubility and Storage

Solubility Soluble in dilute acid and physiological buffers
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC

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