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Puromycin dihydrochloride

Cat. No. PI-160

Structure:

3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Activity:

Broad spectrum antibiotic
Price Qty
50 mg    $ 75.00
Puromycin is a broad spectrum antibiotic and protein synthesis inhibitor produced by Streptomyces alboniger, active in both prokaryotes and eukaryotes. Puromycin is a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase (metallopeptidase). Puromycin is used in cell biology as a selective agent in cell culture systems.

Azzam and Algranati (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes. Proc.Nat.Acad.Sci. 70 3866 PMID: 4590173

Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction. Biochim.Biophys.Acta. 1150 89 PMID: 8334141

Matsumoto and Saitoh H (2016) Puromycin induces SUMO and ubiquitin redistribution upon proteasome inhibition. Biochem. Biophys. Res. Comm. 476(3) 153 PMID: 27181354


Related areas

All small molecules >
All antibacterial agents >


Technical Data

Structure 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
CAS Number 58-58-2
Molecular Weight 544.43
Formula C22H29N7O5.2HCl
Sequence 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Solubility and Storage

Solubility Soluble in water
Appearance White solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity ≥98% (HPLC)

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
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info@iscabiochemicals.com

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France

CliniSciences
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Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
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Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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