PR-39

AM-110-0.5MG 0.5mg 150.00 GBP
AM-110-1MG 1mg 270.00 GBP

Product specification

Sequence: H-RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2
MW: 4719.7
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C229H346N70O40
CAS: 139637-11-9
Solubility Soluble in dilute acid
Long Term Storage: Store dry, frozen and desiccated
Miscellaneous/General:

PR-39 is a 39 amino acid proline-rich cathelicidin. A host defence and immunomodulatory peptide isolated from porcine polymorphonuclear neutrophils. PR-39 is known to induce angiogenesis in vitro and in vivo, through inhibition of HIF-1α degradation by the ubiquitin-proteasome system. PR-39 is a neutrophil chemoattractant and has a non pore-forming antibacterial action distinct from many other antimicrobial peptides. PR-39 also inhibits apoptosis in hypoxic endothelial cells.

Product Literature References

Veldhuizen et al. PLOS ONE (2014) 9(4): e95939

Hennig-Pauka et al. BMC Research Notes (2012) 5: 539

Wu et al. Circulation (2004) 109: 1660-1667

Li et al. Nature Medicine (2000) 6: 49-55