P5091

PI-100-10mg 10mg 75.00 GBP

Product specification

Sequence: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
MW: 348.22
Purity: ≥98% (HPLC)
Appearance: Off-white solid
Formula: C12H7Cl2NO3S2
CAS: 882257-11-6
Solubility Soluble to 10 mM in DMSO
Long Term Storage: We recommend storage desiccated, frozen and in the dark
Miscellaneous/General:

P5091 is a selective and inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 4.2 μM. P5091 displays little or no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases but does have some activity at USP47.  P5091 induces elevated p53 and apoptosis in cancer cell lines and possesses antiangiogenic activity in vivo.

Product Literature References

Weinstock et al (2012) Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. J.Med.Chem. 3 789

Chauhan et al (2012) A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell 22 345 PMID: 22975377