P32/98

PI-090-10MG 10mg 85.00 GBP
PI-090-50MG 50mg 295.00 GBP

Product specification

Sequence: (2S,3S)-2-Amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one hemi-fumarate
MW: 260.35
Purity: 98% by tlc
Appearance: White solid
Formula: C9H18N2OS 1/2C4H4O4
CAS: 136259-20-6
Solubility Soluble in DMSO or in water (up to 20 mg/ml).
Long Term Storage: We recommend storage desiccated, frozen and in the dark
Miscellaneous/General:

P32/98, also known as isoleucyl thiazolidide, is a potent and selective cell permeable inhibitor of dipeptidyl peptidase IV (DPP IV) with a Ki of 130 nM.   P32/98 inhibition of DPP IV prevents degradation of both gastric inhibitory peptide (GIP) and Glucagon-like peptide-1, enhancing insulin secretion. P32/98 improves glucose tolerance, insulin sensitivity and beta-cell glucose responsiveness in diabetic fatty rats following oral administration.

Product Literature References

Pederson et al (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47 1253 PMID: 9703325

Pospisilik et al (2002) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral Ins sensitivity in the VDF Zucker rat. Diabetes 51 2677 PMID: 12196458

Wagner et al (2016) Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation. Neuropeptides. 57 21 doi:10.1016/j.npep.2016.02.007