NSC 632839

PI-080-10MG 10mg 65.00 GBP
PI-080-50MG 50mg 225.00 GBP

Product specification

Sequence: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
MW: 339.86
Formula: C21H21NO.HCl
CAS: 157654-67-6
Long Term Storage: Store dry, dark and frozen

NSC 632839, also known as F6, targets the ubiquitin-proteasome system by inhibiting ubiquitin isopeptidases.  NSC 632839 is able to activate an apoptosome-independent apoptotic pathway which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, and also the involvement of the death receptor pathway

Product Literature References

Aleo et al (2006) Identification of New Compounds That Trigger Apoptosome-Independent Caspase Activation and Apoptosis. Cancer Res. 66(18) 9235 DOI: 10.1158/0008-5472.CAN-06-0702