MG 132

PI-030-5MG 5mg 65.00 GBP

Product specification

Sequence: Z-Leu-Leu-Leu-CHO
MW: 475.63
Purity: >98% by HPLC
Appearance: Freeze dried solid
Formula: C26H41N3O5
CAS: 133407-82-6
Solubility Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL)
Long Term Storage: We recommend storage desiccated, frozen and in the dark
Miscellaneous/General:

MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome  with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy.  It also inhibits TNF-α-induced NF-κB activation and IκBα degradation and induces neurite outgrowth in PC12 cells.  MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.

Product Literature References

Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941 PMID: 11911275

Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572 PMID: 8830056

Ma et al (2020) Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. 30 678 https://doi.org/10.1038/s41422-020-0356-z