PI-030-25MG 25mg 180.00 GBP
PI-030-5MG 5mg 60.00 GBP

Product specification

Sequence: Z-Leu-Leu-Leu-CHO
MW: 475.63
Purity: >98% by HPLC
Appearance: Freeze dried solid
Formula: C26H41N3O5
CAS: 133407-82-6
Solubility May be dissolved in DMSO (45 mg/mL); or DMF (45 mg/mL); or ethanol (45 mg/mL)
Long Term Storage: Store dry, dark and frozen

Specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate)1. Also inhibits calpain (IC50=1.25 µM)Suppresses gastric cancer cell proliferation and induces macro-autophagy2. Activates stress kinases and induces Hsp723. Induces neurite outgrowth1. Blocks NFκB activation by blocking IκB proteolysis (IC50=3 µM)4. Cell permeable.

Product Literature References

1. S Tsubuki et al. J. Biochem. (1996) 119:572
2. WK Wu et al. Autophagy (2010) 6:228
3. AB Meriin et al. J. Biol. Chem. (1998) 273:6373
4. MA Fiedler et al. Am. J. Respir. Cell Mol. Biol. (1998) 19:259