Melittin (synthetic)

AM-050-1MG 1mg 55.00 GBP
AM-050-5MG 5mg 220.00 GBP

Product specification

Sequence: H-GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
MW: 2846.5
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C131H228N38O32
CAS: 20449-79-0
Solubility Soluble in dilute acid and physiological buffers
Long Term Storage: Store dry, dark and frozen
Miscellaneous/General:

Melittin is a cationic, haemolytic component of honey bee venom with utility in cell lysis and liposome lysis which has been extensively studied as a model for antimicrobial peptide-membrane interactions. Synthetic melittin and its fragments induce transient pores in membranes at nanomolar concentrations.  Melittin forms a random coil conformation in dilute aqueous solution, but aggregates into alpha-helical tetramers under conditions of high concentration, salt or pH.  Melittin inhibits Gs and stimulates Gi activity, inhibits protein kinase C and cAMP-dependent protein kinases and is a Na+/K+ ATPase inhibitor.

Product Literature References

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753 PMID: 1847132

Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811 PMID: 9663445

Shi et al (2016) Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice. Appl. Microbiol. Biotechnol. 100, 5059 https://doi.org/10.1007/s00253-016-7400-4