Melittin (Synthetic)

AM-050-1MG 1mg 55.00 GBP
AM-050-5MG 5mg 220.00 GBP

Product specification

Sequence: H-GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
MW: 2846.5
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C131H228N38O32
CAS: 20449-79-0
Solubility Soluble in dilute acid and physiological buffers
Long Term Storage: Store dry, dark and frozen
Miscellaneous/General:

Melittin is a cationic, haemolytic component of honey-bee venom with utility in cell lysis and liposome lysis. It has been extensively studied as a model for antimicrobial peptide-membrane interactions. Synthetic melittin and its fragments induce transient pores in membranes at nanomolar concentrations. Melittin acts as a multimer at micromolar concentrations to create stable pores in membranes. Melittin forms a random coil conformation in dilute aqueous solution, but aggregates into alpha-helical tetramers under conditions of high concentration, salt or pH.

Product Literature References