MDL 28170

PI-020-10MG 10mg 65.00 GBP

Product specification

Sequence: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
MW: 382.45
Purity: ≥95% (HPLC)
Appearance: Freeze dried solid
Formula: C22H26N2O4
CAS: 88191-84-8
Solubility Soluble in DMSO
Long Term Storage: We recommend storage desiccated, frozen and in the dark
Miscellaneous/General:

MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo.

Product Literature References

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513