PS-060-1MG 1mg 125.00 GBP
PS-060-5MG 5mg 495.00 GBP

Product specification

Sequence: Mca-KPLGL-Dap(Dnp)-AR-NH2
MW: 1221.3
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C55H80N16O16
CAS: 720710-69-0
Solubility Soluble in DMSO. Dilute with buffer.
Long Term Storage: Store dark, frozen and desiccated

Mca-KPLGL-Dpa-AR-NH₂ is a broad spectrum synthetic FRET substrate for matrix metalloproteinases including intestinal collagenase (MMP-1), neutrophil collagenase (MMP-8) collagenase 3 (MMP-13), gelatinase A (MMP-2), gelatinase B (MMP-9), and matrilysin (MMP-7) and MMP-17. Addition of an N-terminal lysine improves substrate kcat/Km compared to Mca-PLGL-Dpa-AR-NH₂ (PS-040)

Product Literature References

Devy et al. Cancer Res. (2009) 69: 1517-1526

Walsh L.A. and S. Damjanovski Cell Communication and Signalling (2011) 9:10

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