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LL 37 (human)

Cat. No. AM-001

Structure:

H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH

Other Names:

Ropocamptide, hCAP 18, Cathelicidin, LL 37, LL-37, cathelicidin, LL 37 (human)

Activity:

Host defence peptide derived from the C-terminal of human cathelicidin antimicrobial peptide
Price Qty
1 mg    $ 165.00
LL 37 (human)  is a 37 amino acid host defence peptide derived from the C-terminal of human cathelicidin antimicrobial peptide (CAMP, hCAP18), which has antimicrobial, antitumour, antiviral and immunomodulatory properties and also has physiological functions in chemotaxis, promotion of wound closure, and angiogenesis. In addition to its antimicrobial properties, LL 37 (human) modulates numerous pathways in autoimmune and inflammatory diseases and has a role in the pathogenesis of lupus, RA and atherosclerosis. As a binding partner to Aβ42, LL 37 (human) expression impacts initiation and progression of Alzheimer's disease. LL 37 also has a significant role in human cancer, inducing tumourigenic effects in cancers of the ovary, lung, breast, prostate, pancreas, and also in malignant melanoma.

Kahlenberg and Kaplan (2013) Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J. Immunol. 191(10) 4895 PMID: 24185823

Bandurska et al (2015) Unique features of human cathelicidin LL‐37. BioFactors 41 289 PMID: 26434733

Chen et al (2018) Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer. Cell Physiol.Biochem. 47 1060 PMID: 29843147

Vierthaler et al (2020) Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma. Oncol. Rep. 44 325 PMID: 32627035

Guide to Pharmacology - LL 37


Related areas

All antimicrobial peptides >
All antiviral agents >
All immunology research categories >
All cancer research categories >
All neuroscience research categories >


Technical Data

Structure H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
CAS Number 154947-66-7
Molecular Weight 4493.3
Formula C205H340N60O53
Sequence LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Modifications None

Solubility and Storage

Solubility Soluble in physiological buffers including PBS (>1mg/mL). Soluble in DMSO as a stock
Appearance Freeze dried solid
Storage Store dry, dark and frozen

Batch Specific Data

Purity >95% by HPLC
Certificate of Analysis AM-001-1MG LL-37 0613AE_623c90189fb4b.pdf
Safety Data Sheet LL 37 (human) MSDS_602bef617ecd8.pdf

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

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Tel: 610-994-1134

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BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
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Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
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China

BIOHUB INTERNATIONAL 

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Fax: +86-021-50724961

Orders: sale3@78bio.com

India
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07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
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Fax:+81-3-3352-2196
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