Leupeptin hemisulfate

PI-010-100MG 100mg 225.00 GBP
PI-010-25MG 25mg 100.00 GBP

Product specification

Sequence: Ac-Leu-Leu-Arginal
MW: 475.04
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C20H38N6O4.½H2SO4
CAS: 103476-89-7
Solubility
Long Term Storage: Store dry, dark and frozen
Miscellaneous/General:

A reversible inhibitor of trypsin-like proteases and cysteine proteases.
Inhibits trypsin, plasmin, papain and cathepsin B, H and L1-3. Blocks various apoptotic
pathways in T cells4. Commonly used in cell lysis buffers to protect proteins from
degradation. Typical working concentration is 1 μM (0.5 μg/mL).

Product Literature References

1. T Aoyagi et al. J. Antibiot. (1969) 22: 283
2. AJ Barrett et al. Methods Enzymol. (1981), Pt C, 80: 535
3. CG Knight et al. Biochem. J. (1980) 189: 447
4. A Sarin et al. J. Immunol. (1995) 154: 5806