Leupeptin hemisulfate

PI-010-100MG 100mg 225.00 GBP
PI-010-25MG 25mg 100.00 GBP

Product specification

Sequence: Ac-Leu-Leu-Arginal
MW: 475.04
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula: C20H38N6O4.½H2SO4
CAS: 103476-89-7
Long Term Storage: Store dry, dark and frozen

Leupeptin is a reversible inhibitor of trypsin-like proteases and cysteine proteases, including trypsin, plasmin, papain, cathepsin B, H and L1-3. Leupeptin also blocks various apoptotic
pathways in T cells and can inhibit activation-induced programmed cell death. Leupeptin is widely used in cell lysis buffers to protect proteins from degradation, at a typical working concentration of 1 μM (0.5 μg/mL).

Product Literature References

Aoyagi et al (1969) Leupeptins, new protease inhibitors from actinomycetes. J. Antibiot. 22 283 https://doi.org/10.7164/antibiotics.22.283

Barrett et al (1981) Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol. 1981 80 535 doi:10.1016/s0076-6879(81)80043-2

Sarin et al (1995) A protease-dependent TCR-induced death pathway in mature lymphocytes. J. Immunol. 154(11) 5806 https://www.jimmunol.org/content/154/11/5806