BMAP 28 (bovine)

AM-030-0.5MG 0.5mg 80.00 GBP
AM-030-1MG 1mg 150.00 GBP

Product specification

Sequence: H-GGLRSLGRKILRAWKKYGPIIVPIIRIG-OH
MW: 3131.9
Purity: >95% by HPLC
Appearance: Freeze dried solid
Formula:
CAS:
Solubility Soluble in dilute acid
Long Term Storage: Store dry, frozen and desiccated
Miscellaneous/General:

BMAP 28 is a 28 amino acid bovine myeloid cathelicidin exhibiting multiple activities against bacteria and fungi.  BMAP 28 has an alpha helical structure and this acts to disrupt cell membranes, and can inhibit pan-drug-resistant Acinetobacter baumannii (PDRAB) though interaction with its outer membrane proteins (OMPs).  It can also induce membrane permeabilization and death in human tumour cell lines.

Product Literature References

Risso et al (2002) BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol. Cell. Biol. 22(6) 1926 https://doi.org/10.1128/mcb.22.6.1926-1935.2002

Brogden et al (2007) Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific. Vet. Microbiol. 119 76

Guo et al (2018) A bovine myeloid antimicrobial peptide (BMAP-28) and its analogs kill pan-drug-resistant Acinetobacter baumannii by interacting with outer membrane protein A (OmpA). Medicine 97(42), e12832. https://doi.org/10.1097/MD.0000000000012832